Then, in 1999, Schafer recruited fellow Mopes, B-Face and Dan Lumley and headed to Sonic Iguana in Lafayette IN, to record their debut record "Ill At Ease". After the recording, B-face and Lumley returned to their corners of the country due to geographical distance and commitments of their own. From there, Schafer went on to recruit fellow Chicagoans Pete Mittler and Mike Byrne (formerly Vindictives) to join. After several drummers, Michael Soucy, native to the Rhode Island and DC punk scenes, was enlisted to complete The Methadones. This core lineup has remained consistent since 2001 with five full length records under their belt.
The band announced their split in 2010, citing a declining interest in the Methadones as other projects began to take precident.