Growing up in Mitchell's Plain, Isaac came into contact with hip-hop through breakdance in the mid-eighties, and started to rap soon after. His first group was a duo known as "Bad Influence", who later changed their name to "Trampled Multitude". The group disbanded, and Isaac Mutant went solo.
Founding a new group Plain Madnizz, and K.A.K. (or Koloured Ass Krooks) together with MC Scallywag, as well as joining the group "Parliament" (another group of MC's from Mitchell's Plain) in 2003, releasing the album Amerikaap. Plain Madnizz went on to release an album that same year titled "What Kine" The Album on Cape Flats Uprising, which was Followed by his solo debut Side-Show Freak Vol. 1: Ah!freak-kaans in 2004.