Meller began his career at Columbia Studios in New York in 1969, continuing to work there after Sony Music took CBS over in the 1980s and becoming an integral part of the Sony Music Studios, New York City operation until its closure in 2007. From 2007 to 2011, Meller held the position of senior mastering engineer at Universal Mastering Studios-East in New York, overseeing all of the studios' projects in the city. He currently lives and works in Charleston, S.C at Vlado Meller Mastering.
He is a two-time Grammy Award winner and ten-time nominee.
Meller has been criticized by some for "excessive compression and distortion" in final versions of releases he has mastered in recent years.