She started her music studies at the Central Music School, and went on to earn a doctorate from the Moscow Conservatory. In the Soviet Union she worked with both then-current early music ensembles, Madrigal and The Chamber Music Academy (directed by Alexei Lubimov), while also touring as a solo artist in Moscow, Leningrad, Kiev, Minsk, Sverdlovsk, etc.
In 1989, Sofronitsky moved to the United States, where she worked at the Oberlin College Conservatory of Music in Ohio. In 1990, she moved to Canada, where she pursued an active career in performance and recording in Toronto, partnered with various members of the Tafelmusik Baroque Orchestra. She was a founder and the first Artistic Director of the Academy Concert Series in Toronto. Sofronitsky has been a Canadian citizen since 1994.
In 1999 she received historical performance degrees in harpsichord, fortepiano and early music teaching from the Royal Conservatory in The Hague.
Since 2001 she has lived in the Czech Republic, married to fortepiano builder Paul McNulty, performing and recording on his highly prized instruments an expanded repertoire from C.P.E. Bach to Liszt.