As well as his numerous acting credits, Jameson is notable for briefly becoming the fourth member of the English blues-rock band Foghat, and producing several of their albums. He has since released two solo albums, Nick Jameson - Already Free & Nick Jameson - A Crowd Of One.
Jameson is a prolific actor, having appeared in movies such as Road Trip (with Rade Serbedzija) and Helter Skelter (with Mary Lynn Rajskub, Endre Hules, Keith Szarabajka, John Lacy, and François Chau). He has appeared in many shows, including Criminal Minds (with Nestor Serrano), Alias, The Practice (with Alyson Croft), The West Wing (with Devika Parikh and Tobin Bell), and Days of Our Lives. His voice can be heard in popular cartoon movies, cartoon shows and video games such as Shark Tale, Star Wars: Clone Wars, and The Critic.