In 1976, he broke in professionally as assistant engineer at Clover Studios, Los Angeles, working for Chuck Plotkin, who quickly made him his primary engineer. In 1978, Plotkin started working with Bruce Springsteen, and in 1980, Toby left Clover to become Springsteen's Chief Engineer, a position he would hold for 37 years. After mixing The River, he organized transferring Nebraska from a cassette Springsteen had carried in his pocket for three months, to the album released in 1982. He continued on to record "Born in the U.S.A.", which took 2 1/2 years, and during that time, he became a resident of New York City. Continuing independent projects in New York and Los Angeles, he also recorded many live Springsteen shows on tour. Commencing with the "Tunnel of Love" album, he has worked almost exclusively with Springsteen. Scott parted company with Springsteen in late 2017 to be available for new projects and artists.
He currently works at his own Cabin 6 Studio in Whitefish, Montana.