She debuted as actress with the film "El laab bil nar" directed by Omar Gomai.
In the 50's she got his first hit with the song "Amana Ya Bokra" and began her career in the film business. Later married the director El Sayed Bedeir from whom she had a son who died at war. In 1973, during the Yom Kippur War she would succeed playing the song "Umm al Batal". Among the films that she have made there are : "el Mufattish mabahess" (1960) directed by Hussein Fawzi, "Ghazia men Sonbat" (1967) of El-Sayed Ziada director and "Sultana to Tarab" (1978) director Hassan Al Imam.
Well known in Egypt, Sharifa Fadel is part of that category of interpreters offering a style that straddles between the classical Arabic song and popular music. Many of her songs, musically, has light contamination with Western pop music of the 60s and the voice plan will provide a strong inspiration for the vast array of singers who will become the stars of Chaabi music for years to come.
Even her sister will undertake a career in music, adopting the name of Thana Nada getting good visibility at the popular level but was unable ever to dominate entirely.