From 1925 to 1945, Lillian Fuchs was a member of Perolé Quartet. The violist also collaborated with Budapest String Quartet and Amadeus-Quartett. She made numerous recordings and performed extensively with her brother Joseph Fuchs, joined by Harry on some occasions. They recorded Beethoven's Trio in C Minor, Op. 9, No. 3 for violin, viola and cello together, a hugely successful LP released by Decca in 1951.
A prominent chamber music/viola teacher, Lillian Fuchs had been teaching at the Manhattan School Of Music, Juilliard School, and Aspen Music Festival + School. She also co-founded Blue Hill Music School with her brother Joseph. Fuchs wrote and published three books of etudes, widely used by viola students nowadays.