Maurice Engelen, Nikkie Van Lierop and Oliver Adams were the main artists, with Rembert De Smet, Ferre Baelen, Ludo Camberlin, Jos Borremans, Harry Van Oekel, Luc Van Acker and Wim Daans among the contributors.
When Nikkie left the group, she was replaced by vocalist Ruth McArdle.
Later Deborah Ostrega took over vocal duties.
During summer 2010, the Lords Of Acid are back for an US Sextreme Ball tour with a new lineup : Maurice Engelen, Lacey Conner, Sin Quirin, Murv Douglas and Kirk Salvador.
In 2011, Mea Fisher becomes the new lead singer.
In 2018, Marieke Bresseleers became the new frontwoman.