From 1971 to 1974 Siegel studied composition and philosophy at the University of California, Santa Barbara. After three years there he decided to complete his Bachelor of Arts degree in Århus, Denmark, where he studied with the noted Danish composer Per Nørgård.
Siegel's works show the influence of minimalism (particularly the pulse-based work of Steve Reich), as well as folk, blues, and rock music.
His works have been commissioned by the Kronos Quartet, Evelyn Glennie, Harry Sparnaay, Singcircle, and the Safri Duo.
Wayne Siegel is currently working as professor in electronic music in Aarhus, Denmark.