He began performing his songs on the radio station El Telégrafo for a program called "La hora agrícola". He then formed the group "Vera Santos-Rubira".
He also formed the group "Los Porteños" with the singer Olimpo Cardenas. Until then Cardenas had been a tango singer but asked Rubira to teach him to sing pasillo music. He also influenced the singers Fresia Saavedra, Pepe and Julio Jaramillo, among others. As teenagers, he and Julio Jaramillo once worked together at a shoe store, and after work he would invite Jaramillo over to teach him some songs. His friends Olimpo Cardenas and Julio Jaramillo went on to international fame singing the type of music Rubira taught them.
Rubira was awarded the National Prize in Art "Premio Eugenio Espejo" in 2008 from the President of Ecuador.
Carlos Rubira Infante wrote over 400 songs. Among them are:
Guayaquileño madera de guerrero
Guayaquil pórtico de oro
Ambato tierra de flores
En las lejanías
Lo mejor de mi tierra
El Cóndor Mensajero (himno del migrate Alauseño a lo largo y ancho del mundo)
Mi primer amor
Quiero verte madre
Historia de amor
Desde que te fuiste
En las lejanías\
Por qué (pasillos)
Venga conozca El Oro (pasacalle)
El bautizo (albazo)
Pedazo de bandido (aire típico)