Pamela studied at the "Beethoven Conservatory of Music and Voice" in Germany. She joined Flo Ziegfeld's "Broadway Follies" after her return to America. She was voted Miss St. Louis in 1926.
She was featured in Ripley's Believe It or Not for memorizing a record 10,000 songs. She led the all-girl orchestra and Odeon Theatre house band the Musical Pirates, said by some to be the first all-female orchestra, and hosted radio programs including The Encouragement Hour, Kansas City, and Gal About Town, Fresno.
She produced only one album, Into Outer Space With Lucia Pamela (circa 1969, Gulfstream and later on L'Peg), whose songs are mostly about an imaginary trip to the moon. The song "Flip Flop Fly" was featured on the radio by Bob and Ray in 1973, but the album was all but forgotten before being reissued in 1992 (record label: Arf! Arf!, recorded from a vinyl source and produced by Irwin Chusid) to greater acclaim.
She also produced a cartoon coloring book, Into Outer Space with Lucia Pamela in the Year 2000. In 1994, the pop group Stereolab recorded a tribute to her, "International Colouring Contest", on their album Mars Audiac Quintet; the intro of the song includes a voice sample of Pamela herself. She died in 2002, age 98, in Los Angeles.