Ledford crafted thousands of musical instruments. His banjos, violins, guitars, mandolins, and dulcimers are sought by musicians worldwide. The Smithsonian Institution houses three of his creations— a fretless banjo, an Appalachian dulcimer and a dulcitar, which he copyrighted. He played 13 musical instruments.
Patriarch of The Ledford Family, Homer was the husband of Colista Ledford and they are the parents of Cindy Ledford & Julie Ledford.