She was born in Brooklyn, New York, and studied piano in Switzerland and then at the New York School of Music. In 1925, she co-wrote the music to the hit song "Don’t Wake Me Up, Let Me Dream", with lyrics provided by Wolfe Gilbert. She also wrote the hit songs "Ramona", "In a Little Spanish Town", "It Happened in Monterey", and "I Understand". She was particularly noted for her Latin-tinged songs.
She died at Glen Cove, Long Island, in 1978 at the age of 73.
Wayne collaborated with several lyricists including L. Wolfe Gilbert, Kim Gannon, Billy Rose, Mitchell Parish, Sam Lewis, Joe Young and Al Lewis.
|Agustín Magaldi, Pedro Noda, Rosita Quiroga||Ramona Agustín Magaldi, Pedro Noda, Rosita Quiroga - Aquellas Canciones - Vol. III (Album)||RCA Victor||Venezuela||1973||Sell This Version|
|6470||Arc Angels (2)||Ramona Arc Angels (2) - Guitare Hawaienne (LP)||Les Tréteaux International||6470||France||Unknown||Sell This Version|
|SH 273||Various||In A Little Spanish Town / It Happened In Monterey / Who Made Little Boy Blue? / Little Man You've Had A Busy Day / Ramona / His Majesty, The Baby Various - All Our Own Work (LP, Comp)||World Records (6)||SH 273||UK||1978||Sell This Version|
|AD-05606||Alfredo Kraus||Ramona (as M. Wayne Jones) Alfredo Kraus - Homenaje A Una Voz (CD, Album, Comp)||Alfa Delta||AD-05606||Spain||1999||Sell This Version|