Sathe began his professional career in Bombay in 1951, working with a local Indian vocalist by the name of Kelkar. He moved to the United Kingdom in 1956, and joined a group formed by Ayana Deva Angadi, known as the Asian Music Circle. He worked with visiting Indian sitarist Bhaskar Chandavarkar, and in 1961 they played together with the harmonica virtuoso Larry Adler. This was Sathe’s first contact with jazz.
In 1965 Sathe began his Indo Jazz Fusion performances and recordings with John Mayer and Joe Harriott, a musical relationship that lasted until 1970. In 1967 he was invited with his trio (with Diwan Motihar, sitar, and Kasan Thakur, tamboura) to join the trio of jazz pianist Irène Schweizer (together with Barney Wilen, Mani Neumeier, Uli Trepte and Manfred Schoof). They appeared at the Donaueschingen Festival and Berlin Jazz Tage. The album “Jazz Meets India” was recorded in Villingen (Black Forest).
From 1970–73 he worked and toured with Julie Felix and Danny Thompson. Through Danny, in 1974, he joined The John Renbourn Group with John Renbourn, Jacqui McShee and Tony Roberts, touring UK, Europe and USA, and producing records, including “A Maid in Bedlam” and “The Enchanted Garden“.
In the 1980s, Sathe formed a group with Tony Roberts which included the dancer Shobhana Jeyasingh, and toured UK and Northern Ireland. With the singer Alisha Sufit and group, he made the record “Magic Carpet”. From 1965–1993 he regularly accompanied the late singer/dancer Surya Kumari in recitals and teaching workshops.
Apart from these, Kesh has made numerous incidental recordings, worked for television, radio, and taught tabla until 2003.