Owens enjoyed a string of hits with The Shirelles throughout the 1960s. Through marriages, she became Shirley Owens Alston and later, Shirley Alston Reeves. She left The Shirelles in 1975 to begin a solo career, recording under the name Lady Rose (2). That same year, she recorded an album entitled With A Little Help From My Friends, after the hit song by Beatles.
She was inducted into the Rock 'n' Roll Hall of Fame in 1996