Myrrh was started in 1972 as a division of Word Records. It was established by Billy Ray Hearn. Myrrh was the mainstay of Word's "popular music" sounding religious issues. At one point, Word was issuing more titles on Myrrh than Word itself. The label took a five year hiatus beginning in 2000 before being relaunched by parent company Word Entertainment under the name Myrrh Worship in 2005.

The biggest "find" for Myrrh was singer Amy Grant.

Another big "find" for Myrrh was Petra (9), a popular Christian rock and roll group, but they never achieved the pop music status of Amy Grant.

The logo has changed over the years, from simply the word "myrrh" in lower case, used during the 1970s and 1980s, to two different stylized "M" logos, used in the late 1980s and throughout the 1990s.